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Pharmacogenetics is the study of how an individual's genes affect their response to drugs. Although variability in drug response may depend on many factors, genetic factors have been shown to play a significant role. Genes that influence drug response code for drug receptors or targets for examples, or enzymes that are involved in drug metabolism or drug clearance. One family of drug metabolizing enzymes, the cytochrome P450s (CYP450s), has been extensively studied, and as a result, knowledge in this area of pharmacogenetics represents one of the most well-established and substantially documented. At Seryx, we have gathered the publicly available published information on the CYP450s as it relates to the metabolism and clearance of a selected group of drugs (see Pharmacogenetics Drug List). We organized this information so that we can provide physicians with a comprehensive highly focused overview of these published studies as they relate to each patient's drug regimen and CYP450 genetic test results. This overview, our Signature Genetics™ Report, is an educational tool designed to help physicians integrate this information into the clinic.
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