We recommend the following links for anyone interested in finding out more about pharmacogenetics.

Academic and applied research sites

http://www.boomer.org/pkin/
An encyclopedic and extensive online resource dedicated to the study of Pharmacokinetics and Pharmacodynamics (with an emphasis on PK). Provides links to online courses and tutorials, modeling freeware and software and a popular discussion list frequented by professionals and researchers.

http://www.pharmgkb.org/index.jsp
PharmGKB is a publicly available Internet research tool developed by Stanford University with funding from the National Institutes of Health (NIH) and is part of the NIH Pharmacogenetics Research Network (PGRN), a nationwide collaborative research consortium. Its aim is to aid researchers in understanding how genetic variation among individuals contributes to differences in reactions to drugs.

The PharmGKB database is a central repository for genetic, genomic, molecular and cellular phenotype data and clinical information about people who have participated in pharmacogenomics research studies. The data includes, but is not limited to, clinical and basic pharmacokinetic and pharmacogenomic research in the cardiovascular, pulmonary, cancer, pathways, metabolic and transporter domains. The contributers tab contains the links to all of the projects submitting data to the PharmGKB.

http://www.preskorn.com/
This site features the works of Sheldon H. Preskorn, M.D., an internationally recognized, board certified psychiatrist and researcher in the area of psychiatric medications.

http://www.anaesthetist.com/physiol/basics/metabol/cyp/Findex.htm#cyp.htm
Primer on Cytochrome P450s from a biochemical and pharmacological perspective from the Worldwide Physiologist.

http://drnelson.utmem.edu/P450lect.html
An excellent introduction to CYP450s by David Nelson, Associate Professor, University of Tenessee College of Medicine. Here is his lab home page : http://www.utmem.edu/molecular_sciences/directories/faculty/d_nelson.htm

http://www.hanstenandhorn.com/index.html
Hansten and Horn Drug Interaction site by the authors of the The Top 100 Drug Interactions, an authoritative drug interaction resource intended for all practitioners.

Phillip D Hansten (PharmD) is Professor of Pharmacy at the University of Washington in Seattle.

John R. Horn (Pharm.D., FCCP) is Professor of Pharmacy and Associate Director of the University of Washington Medical Center Pharmacy Department

http://www.imm.ki.se/CYPalleles/
Web page of the Human Cytochrome P450 (CYP) Allele Nomenclature Committee which offers detailed information on a number of Cytochrome P450 genes and their alleles.

http://medicine.iupui.edu/flockhart/table.htm
A CYP450 based drug interaction resource by Dr. David Flockhart (MD PhD) Chief of the Division of Clinical Pharmacology at the Indiana University School of Medicine.



Scientific Journals, Publishing and Literature search sites

http://www.nature.com/tpj/index.html
The Pharmacogenomics Journal is dedicated to the rapid publication of original research on basic pharmacogenomics research and its clinical applications. Publishing six times a year, the journal aims to provide the highest caliber of coverage concerning the effects of genetic variablity on drug toxicity and efficacy, the characterization of polymorphisms relevant to drug action, and the identification of novel genomic targets for drug development.

http://www.nature.com/clpt/
Clinical Pharmacology and Therapeutics, a journal from the Nature Publishing Group, published monthly.

http://jcp.sagepub.com/
The Journal of Clinical Pharmacology, published by the American College of Clinical Pharmacology, presents original research, reviews, commentaries, case reports on a wide variety of drug therapies.

http://www.blackwellpublishing.com/journal.asp?ref=0306-5251
The Journal of The British Pharmacological Society presenting original papers, reviews, editorials, letters, book reviews related to all aspects of drug action in humans.

http://www.springerlink.com/content/100413/
The European Journal of Clinical Pharmacology publishes original papers, short communications, and letters to the editors on all aspects of clinical pharmacology and drug therapy in humans.

http://highwire.stanford.edu/
A division of the Stanford University Libraries, HighWire Press hosts the largest repository of high impact, peer-reviewed content, with 1185 journals and 4,885,669 full text articles from over 140 scholarly publishers. HighWire-hosted publishers have collectively made 1,948,731 articles free. With their partner publishers they produce 71 of the 200 most-frequently-cited journals.

http://www.pubmedcentral.nih.gov/
PubMed Central (PMC) is the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature.

http://searchmedica.com/
SearchMedica is a search engine that uses proprietary technology to find and index documents on the Internet. With guidance from an advisory board of specialty physicians and our staff editors, SearchMedica scans well-known, credible journals, systematic reviews, and evidence-based articles that are written and edited for clinicians practicing in primary care and all major specialties. Using similar expertise, SearchMedica also selects and scans patient-directed websites, online CME courses, and government databases of clinical trials and practice guidelines.



Government sites

http://www.nigms.nih.gov/Initiatives/PGRN
A National Institutes of General Medical Sciences site featuring the Pharmacogenetics Research Network (PGRN). The PGRN is a nationwide collaboration of scientists studying the effect of genes on people's responses to a wide variety of medicines

http://www.cc.nih.gov/training/training/principles.html
The NIH (National Institutes of Health) Clinical Center home page for their "Principles of Clinical Pharmacology" weekly lecture series, covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics.

http://medlineplus.gov/
MedlinePlus brings together authoritative information from NLM, the National Institutes of Health (NIH), and other government agencies and health-related organizations. Preformulated MEDLINE searches are included in MedlinePlus and give easy access to medical journal articles. MedlinePlus also has extensive information about drugs, an illustrated medical encyclopedia, interactive patient tutorials, and latest health news.

http://www.cdc.gov/genomics/training/perspectives/pharmaco.htm
Centre for Disease Control resource page on Pharmacogenomics from a public health perspective.

http://www.genetests.org/
A publicly funded (NIH) medical genetics information resource developed for physicians, other healthcare providers, and researchers.

http://www.nlm.nih.gov/medlineplus/genetictesting.html
The MedlinePlus resource page for genetic testing. Contains many useful links ranging from basic overviews of the science behind genetic testing to genetics in the news to genetic testing policies by various government and medical bodies.

http://www.genome.gov/
The primary NIH organization for genetic testing research

http://clinicaltrials.gov/
ClinicalTrials.gov is a registry of federally and privately supported clinical trials conducted in the United States and around the world. ClinicalTrials.gov gives you information about a trial's purpose, who may participate, locations, and phone numbers for more details.

http://www.ncbi.nlm.nih.gov/
Established in 1988 as a national resource for molecular biology information, NCBI creates public databases, conducts research in computational biology, develops software tools for analyzing genome data, and disseminates biomedical information - all for the better understanding of molecular processes affecting human health and disease.

http://www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed
PubMed provides access to citations from biomedical literature. PubMed was developed by the National Centre for Biotechnology Information at the National Library of Medicine located at the US National Institutes of Health.

http://www.ncbi.nlm.nih.gov/About/primer/pharm.html
A science primer on Pharmacogenomics from NCBI (National Centre for Biotechnology Information



Medical and Bio-Scientific Association sites

http://www.nchpeg.org/
Established in 1996 by the American Medical Association, the American Nurses Association and the National Human Genome Research Institute, the National Coalition for Health Professional Education in Genetics (NCPHEG) is an "organization of organizations" committed to a national effort to promote health professional education and access to information about advances in human genetics.

http://www.aapspharmaceutica.com/inside/focus_groups/PGX/index.asp
American Association of Pharmaceutical Scientists PGx focus group home page chaired by Dr Majid Moridani, Assistant Professor Texas Tech University School of Pharmacy

http://www.ama-assn.org/ama/pub/category/3671.html
American Medical Association Current Topics in Genetics and Medicine resource page.

http://www.ama-assn.org/ama/pub/category/2306.html
American Medical Association Pharmacogenomics page

http://www.bps.ac.uk/site/cms/contentChapterView.asp?chapter=1
Homepage of the British Pharmacological Society

http://www.accp1.org/
Homepage of the American College of Clinical Pharmacology



Public Health Advocacy Groups

http://www.genewatch.org/
UK based not for profit policy research and public interest group devoted to protecting and promoting the public's interest with respect to advancements in genetic engineering and medical genetics.

http://www.phgfoundation.org/
Home page of the Public Health Genomics Foundation, an independent international charity working to achieve the responsible and evidence based application of biomedical science for health.

http://www.gene-watch.org/index.html
The Council for Responsible Genetics fosters public debate about the social, ethical and environmental implications of genetic technologies. CRG works through the media and concerned citizens to distribute accurate information and represent the public interest on emerging issues in biotechnology.

http://www.personalizedmedicinecoalition.org/
The Personalized Medicine Coalition (PMC) representing a broad spectrum of academic, industrial, patient, provider and payer communities, seeks to advance the understanding and adoption of personalized medicine concepts and products for the benefit of patients.

The PMC educates federal and state policymakers and private sector healthcare leaders about personalized medicine, helping them understand the science, the issues and what is needed for the positive evolution of personalized medicine.



Miscellaneous Blogs

http://thepersonalgenome.com/
Blog commenting on "Genomics as a medical tool and lifestyle choice"

http://blogs.wsj.com/health/
WSJ's blog on health and the business of health.

http://labsoftnews.typepad.com/lab_soft_news/
A blog written by Dr. Bruce Friedman, Emeritus Professor of Pathology in the Department of Pathology at the University of Michigan Medical School in Ann Arbor, Mich. focused on Pathology Informatics and the Clinical Laboratory. Presented by the Pathology Education Consortium (PEC).